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pentobarbital will lessen the level or impact of guanfacine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Potent or reasonable CYP3A4 inducers considerably reduce guanfacine plasma concentrations and elimination 50 %-daily life.pentobarbital will decrease the extent or effect of fentanyl by affecting hepati